The SaferWorldbyDesign Blog

BlogPhoto
Data Science at SaferWorldbyDesign

SaferWorldbyDesign's expertise in data science combines technical expertise with strategic thinking, identifying key data sources to analyze and interpret the data and developing predictive models to mitigate potential chemical risks.

BlogPhoto
SaferWorldbyDesign: 2023 SOT Annual Meeting & ToxExpo in Nashville

SaferWorldbyDesign - We will be participating in the Society of Toxicology (SOT) Annual Meeting and ToxExpo in Nashville!

BlogPhoto
FDA Modernization Act 2.0 becomes law

Recently, the FDA Modernization Act 2.0 became law in the US, and crucially included a provision that ends the requirement of animal testing for new drugs.

BlogPhoto
SafeDose releases ToxCalc!

ToxCalc! is a website purpose-built for toxicologists and other scientific professionals to help us do routine calculations.

BlogPhoto
TEAM mastery joins SaferWorldbyDesign

Born in 2008 as a dedicated REACH consulting company, TEAM mastery now provides a range of services in Chemical Regulatory Affairs.

BlogPhoto
How can Knowledge Graphs improve research in safety and risk assessment?

The term Knowledge Graph describes a new type of database technology that is applied to store data about a specific domain and to query the database with questions in natural language.

BlogPhoto
Interested in using a Next Generation Risk Assessment Solution?

RISK-HUNT3R, short for “RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs"

BlogPhoto
SWBD Provider SenzaGen obtains OECD approval for GARD®skin

SenzaGen today announced that the Company has obtained approval from the OECD for GARD®skin as a test guideline for non-animal skin sensitization.

BlogPhoto
SaferWorldbyDesign to provide services on Scientist.com and Science Exchange

We are proud to announce that the catalog of SaferWorldbyDesign products and services is now available through both the Science Exchange and Scientist.com networks.

BlogPhoto
SaferWorldbyDesign Internship

This internship program is organised by Edelweiss Connect, GmbH, and SaferWorldbyDesign partners. Internships will run for six months with an emphasis on virtual work. Opportunities to visit and be hosted by SaferWorldbyDesign partners will also be considered.

BlogPhoto
How to Foster ‘New Approach Methodology’ Toxicologists

The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs will become increasingly accepted by regulators, included in legislation, and consequently more often implemented by industry.

BlogPhoto
Data analysis and visualization

Reliable analysis and consumption of data should be based on a foundation of sound data preparation, well-prepared metadata, data processing protocols, and reliable exposure of data through interfaces to end-user applications for data analysis, risk, and safety assessment.

BlogPhoto
Case Studies in Skin Sensitization Assessment using OECD Guidance

Skin sensitization assessments for chemicals, cosmetics, and many pharmaceuticals are required by regulatory bodies for hazard assessment and approval. In June 2021, the Organization for Economic Co-operation and Development (OECD) published the new guideline (TG 497) for skin sensitization.

BlogPhoto
JRC Data Visualization: Extrapolating from acute to chronic toxicity in vitro

An important question that was addressed within the EU-ToxRisk project relates to the extrapolation from acute to chronic effects of toxicants.

BlogPhoto
Why choose the HepaRG™ cell model for NAFLD investigation?

Nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease worldwide, is rapidly becoming the predominant cause of end-stage liver disease and a leading indication for liver transplantation.

BlogPhoto
SaferWorldbyDesign: Trusted reproducible evidence supporting data-driven decisions

This blog post presents a collection of perspectives that elaborate our vision of reliable and reproducible science supporting product and risk assessment as presented by us this year at the Precision Health conference co-organized by MCBIOS and MAQC.

BlogPhoto
Evaluating the skin sensitisation potential of a squaric acid

The SaferSkin™ Sensitization application implements three well-adopted defined approaches to perform an integrated analysis of the OECD-approved in vitro tests (DPRA, KeratinoSens™, h-CLAT) for assessment of skin sensitisation potential.

BlogPhoto
OECD acceptance of Test Guideline 497 (TG 497)

The recent OECD acceptance of TG 497 for defined approaches for skin sensitization marks an important milestone.

BlogPhoto
Provision of HepaRG™ on SaferWorldbyDesign

HepaRG™ has been manufactured and distributed for many years by Biopredic International, now part of Wepredic. We realized in recent years the increasing need for the development of HepaRG™ infrastructure and services to keep up with the increasing requirements of the HepaRG™ research community and requests from our customers.

BlogPhoto
Dynamic gene expression profiling of the HepaRG™ cell line

A better molecular characterization of a cell line is a prerequisite for well-planned, educated, and targeted experimentation.

BlogPhoto
Working as a Community on Data Integrity from Research through to Practice

An important commitment we are making is to ensure data integrity across the journey from research to practice, from case study work to service execution, from study planning through data generation to downstream consumption.

BlogPhoto
High-throughput prediction of human organ toxicity

This innovative method (Su et al. 2016) was awarded with the Lush Science Price 2016 and combines cell-based assays with bioinformatics. The method predicts specifically toxicity to renal proximal tubular cells, which are one of the main targets for chemical-induced toxicity in the kidney.

BlogPhoto
HepaRG™ ability to predict drug-cholestatic liability

Drug-induced liver injury (DILI) accounts for more than 50% of acute liver failure and constitutes therefore a major concern for the pharmaceutical industry in drug pre-and post-marketing scenarios.

BlogPhoto
HepaRG™ goes digital

For many years HepaRG™ has provided a valuable liver cell line for research applications.

BlogPhoto
SaferWorldbyDesign COVID-19 Data Initiative

Data is the gold of scientific prospecting, whether supporting research publications in academia or product development in industry.

BlogPhoto
Launch of the EU-ToxRisk Commercial Platform

The EU-ToxRisk Commercialisation Platform was launched at the EU-ToxRisk Stakeholder meeting in Egmond, the Netherlands on 12 February.

BlogPhoto
Integrated Approaches to solving Skin Safety Assessment problems

Skin safety is one of the most important goals of the consumer products industry.

BlogPhoto
SBX’s Taxila™ adds more power to SaferWorldbyDesign

Taxila™ is a platform that aggregates the tons of data produced every day in natural text and converts it to actionable insights.

BlogPhoto
Why Biopredic and Eurosafe join SaferWorldbyDesign

Dr. Christophe Chesné, the founder and CEO of Biopredic International and Eurosafe, explains why his two companies are founding partners of SaferWorldbyDesign.

BlogPhoto
Making AI available to companies, large and small

Co-founder and CEO Tom Bell explains why Vertex Laboratories is a founding member of SaferWorldbyDesign.